BioVision Proteins
Human CellExp™ Biotinylated PD-L1, Human Recombinant
- SKU:
- P1422-50
Description
Human CellExp™ Biotinylated PD-L1, Human Recombinant is available at Gentaur for Next week delivery.
Biomolecule/Target:
Alternates names: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1
Synonyms: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1
Background Information: Human Programmed Cell Death 1 Ligand-1 (PD-L1) is also known as CD274 and B7-H1) is a type I transmembrane protein which binds to its receptor, Programmed Cell Death protein 1 (PD-1). PD-L1 is widely distributed on leukocytes, nonhematopoietic cells, and in nonlymphoid tissues including islets. PD-L1 and PD-1 pathway serves as an “immune checkpoint” and its blockade is a highly promising therapy for a broad spectrum of cancers.
Reconstitution Instructions:
NCBI Gene Symbol: CD274
Gene ID: 29126
NCBI Accession: Q9NZQ7
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
False |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Activity (Specifications/test method): |
BioVision’s Biotinylated Human Recombinant PD-L1 has been tested for its biotin content (2-3 biotins per PD-L1 as determined by K811-100) and ability to bind Human PD-1 (Cat. No. 7498) in a functional ELISA with a linear range of 2-125 ng (0.02–1.25 |
Molecular Weight: |
The protein is fused with 6×His tag at the N-terminus, has a calculated MW of 26.4 kDa. The protein migrates as 35 -40 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
Storage Temperature: |
-20ºC |
Shelf Life: |
12 months |
Concentration: |
0.5 mg/ml |
Appearance: |
Sterile Filtered colorless solution |
Handling: |
Centrifuge the vial prior to opening. |