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Common genetic substrates of alcohol and substance use disorder severity revealed by pleiotropy detection against GWAS catalog in two populations.
Alcohol and other substance use disorders (AUD and SUD) is a complex disease that postulates have a polygenic inheritance and frequent comorbidity with other disorders. The comorbidity may arise partly through genetic pleiotropy. Identification of specific gene variants accounting for most of the variance in this disorder have yet to be achieved. We describe a flexible strategy that takes a variant properties association data base […]