Human CellExp™ Biotinylated PD-L1, Human Recombinant

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SKU:
P1422-50
€185
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Description

Human CellExp™ Biotinylated PD-L1, Human Recombinant is available at Gentaur for Next week delivery.

Biomolecule/Target:

Alternates names: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1

Synonyms: Programmed Cell Death 1 Ligand 1, PDL1, PDCD1L1, CD274, B7 homolog 1, B7H1, B7-H1

Background Information: Human Programmed Cell Death 1 Ligand-1 (PD-L1) is also known as CD274 and B7-H1) is a type I transmembrane protein which binds to its receptor, Programmed Cell Death protein 1 (PD-1). PD-L1 is widely distributed on leukocytes, nonhematopoietic cells, and in nonlymphoid tissues including islets. PD-L1 and PD-1 pathway serves as an “immune checkpoint” and its blockade is a highly promising therapy for a broad spectrum of cancers.

Reconstitution Instructions:

NCBI Gene Symbol: CD274

Gene ID: 29126

NCBI Accession: Q9NZQ7

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
False
Source:
HEK293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Activity (Specifications/test method):
BioVision’s Biotinylated Human Recombinant PD-L1 has been tested for its biotin content (2-3 biotins per PD-L1 as determined by K811-100) and ability to bind Human PD-1 (Cat. No. 7498) in a functional ELISA with a linear range of 2-125 ng (0.02–1.25
Molecular Weight:
The protein is fused with 6×His tag at the N-terminus, has a calculated MW of 26.4 kDa. The protein migrates as 35 -40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Storage Temperature:
-20ºC
Shelf Life:
12 months
Concentration:
0.5 mg/ml
Appearance:
Sterile Filtered colorless solution
Handling:
Centrifuge the vial prior to opening.
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