K48-linked Di-Ubiquitin

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SKU:
6415-50
$183
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Description

K48-linked Di-Ubiquitin is available at Gentaur for Next week delivery.

Substrate for defined length polyubiquitination

Biomolecule/Target:

Alternates names:

Synonyms: K48-linked Di-Ubiquitin

Background Information: Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These di-ubiquitin chains are generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting the chain length.

Reconstitution Instructions: N/A

NCBI Gene Symbol: N/A

Gene ID: N/A

NCBI Accession: N/A

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Rabbit
Recombinant:
N/A
Source:
N/A
Purity by SDS-PAGE:
≥95%
Assay:
Western Blot
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
17.139 kDa (Band migrates faster on gels)
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
2.5 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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