K48-linked Tetra-Ubiquitin

(No reviews yet) Write a Review
SKU:
6417-25
€185
Frequently bought together:

Description

K48-linked Tetra-Ubiquitin is available at Gentaur for Next week delivery.

Substrate for defined length polyubiquitination

Biomolecule/Target:

Alternates names:

Synonyms: K48-linked Tetra-Ubiquitin

Background Information: Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These tetra-ubiquitin chains are generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting the chain length.

Reconstitution Instructions: N/A

NCBI Gene Symbol: N/A

Gene ID: N/A

NCBI Accession: N/A

View AllClose

Additional Information

Size:
25 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Rabbit
Recombinant:
N/A
Source:
N/A
Purity by SDS-PAGE:
≥95%
Assay:
Western Blot
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
34.233 kDa (Band migrates faster on gels)
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
2.5 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
View AllClose

0 Reviews

View AllClose