Human CellExp™ Nectin-4, Mouse Recombinant

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SKU:
P1477-50
£135.37
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Description

Human CellExp™ Nectin-4, Mouse Recombinant is available at Gentaur for Next week delivery.

Transmembrane glycoprotein that involved in cell adhesion through trans-homophilic and -heterophilic interactions

Biomolecule/Target:

Alternates names: NECTIN4, LNIR, PRR4, PVRL4

Synonyms: NECTIN4, LNIR, PRR4, PVRL4

Background Information: Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life. Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis. Its expression is not detected in the corresponding normal tissues.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: NECTIN 4

Gene ID: 71740

NCBI Accession: Q8R007-1

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
False
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95%
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Mouse Nectin-4, His Tag at 5 μg/mL (100 μL/well) can bind Human PVRL1 / NECTIN1 Protein, Fc Tag with a linear range of 0.039-1.25 μg/mL
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.2 kDa. The protein migrates as 38-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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