Human CellExp™ Nectin-2 / CD112, Human Recombinant

(No reviews yet) Write a Review
SKU:
P1371-50
€185
Frequently bought together:

Description

Human CellExp™ Nectin-2 / CD112, Human Recombinant is available at Gentaur for Next week delivery.

Modulator of T-cell signaling.

Biomolecule/Target: NECTIN2

Alternates names: CD112, Nectin-2, PVRL2

Synonyms: CD112, Nectin-2, PVRL2

Background Information: Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 100 µg/ml.

NCBI Gene Symbol: NECTIN2

Gene ID: 5819

NCBI Accession: Q92692

View AllClose

Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per 1 μg of protein
Activity (Specifications/test method):
Measured by its binding ability in a functional ELISA
Biological activity:
Immobilized Human PVRIG, Mouse IgG2a Fc Tag, low endotoxin at 2 μg/mL (100 μL/well) can bind Human Nectin-2, His Tag with a linear range of 0.078-0.625 μg/mL
Results:
N/A
Molecular Weight:
37.4 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
View AllClose

0 Reviews

View AllClose