Human CellExp™IL-2, Human Recombinant

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SKU:
P1385-50
€185
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Description

Human CellExp™IL-2, Human Recombinant is available at Gentaur for Next week delivery.

A regulator of lymphocyte activities

Biomolecule/Target:

Alternates names: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Synonyms: T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.

Background Information: Interleukin-2 (IL-2) is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. IL-2 is one of the key cytokines for the immune system, tolerance and immunity. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma in cancer immunotherapy with long term disease control. In addition to being used as monotherapy, IL-2 can also be combined with other anticancer immunotherapies, such as adoptive cell transfer, vaccination, and blockade of immune checkpoint inhibitory molecules, such as cytotoxic T lymphocyte-associated antigen 4 and programmed death 1 monoclonal-antibodies as a promising treatment for metastatic cancer.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: IL2

Gene ID: 3558

NCBI Accession: P60568

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
FAUX
Source:
HEK 293 cells
Purity by SDS-PAGE:
> 95% by SDS - PAGE
Activity (Specifications/test method):
ED50 is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line) using BioVision’s Quick Cell Proliferation colorimetric Assay Kit Plus (
Molecular Weight:
16 kDa with a 6×His tag at the C-terminus
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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