BioVision Proteins
Human CellExp™ Erythropoietin Receptor
- SKU:
- P1638-50
Description
Human CellExp™ Erythropoietin Receptor is available at Gentaur for Next week delivery.
Mediates erythropoietin-induced erythroblast proliferation and differentiation
Biomolecule/Target:
Alternates names: EPOR, EPO-R
Synonyms: EPOR, EPO-R
Background Information: Erythropoietin Receptor is a member of the cytokine receptor family. It mediates erythropoietin-induced erythroblast proliferation and differentiation, activation of Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor plays a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.
Reconstitution Instructions: Reconstitute to a concentration of 0.1-0.5 mg/ml using sterile distilled water
NCBI Gene Symbol:
Gene ID: 2057
NCBI Accession: P19235, NP_000112.1
Additional Information
Size: |
50 μg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
1 |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥ 95% by SDS-PAGE |
Endotoxin Level: |
< 0.1 EU/μg of the protein as determined by LAL method |
Biological activity: |
Measured by its ability to inhibit Epo-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 60-300 ng/ml in the presence of 0.2 U/ml of Recombinant Human EPO Receptor/EPOR. |
Results: |
Measured by its ability to inhibit Epo-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 60-300 ng/ml in the presence of 0.2 U/ml of Recombinant Human EPO Receptor/EPOR. |
Molecular Weight: |
The protein migrates as a band at ~55-60 kDa band in SDS-PAGE. |
Storage Temperature: |
-20ºC |
Shelf Life: |
12 months |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |