Human CellExp™ E-Cadherin /ECAD /Cadherin-1/CD324, (Fc Tag), Human Recombinant

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SKU:
P1522-50
€185
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Description

Human CellExp™ E-Cadherin /ECAD /Cadherin-1/CD324, (Fc Tag), Human Recombinant is available at Gentaur for Next week delivery.

Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells.

Biomolecule/Target:

Alternates names: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Synonyms: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Background Information: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile water. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C

NCBI Gene Symbol: CDH1

Gene ID: 999

NCBI Accession: P12830

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Additional Information

Size:
50 μg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
HEK293 cells
Purity by SDS-PAGE:
>95%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.3 kDa. The protein migrates as 100 kDa and 120 kDa Cadherin, a 48 kDa Propeptide under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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