Human CellExp™ E-Cadherin /ECAD /Cadherin-1/CD324 Protein, human recombinant

Human CellExp™ E-Cadherin /ECAD /Cadherin-1/CD324 Protein, human recombinant is available at Gentaur for Next week delivery.

Involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells.

Biomolecule/Target: Cadherin-1

Alternates names: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Synonyms: Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO

Background Information: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: CDH1

Gene ID: 999

NCBI Accession: P12830