BioVision Proteins
Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant
- SKU:
- P1492-10
Description
Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.
Acts as a decoy receptor that competes with death receptors for ligand binding
Biomolecule/Target:
Alternates names: TNFRSF6B, DCR3, TR6, M68
Synonyms: TNFRSF6B, DCR3, TR6, M68
Background Information: Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: CFD
Gene ID: 8771
NCBI Accession: O95407-1
Additional Information
Size: |
10 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
True |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
>95% |
Endotoxin Level: |
Less than 1.0 EU per μg by the LAL method. |
Activity (Specifications/test method): |
Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Human DcR3, Fc Tag with a linear range of 5-20 ng/mL |
Molecular Weight: |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |