Human CellExp™ Tim-1, Fc Tag, Human Recombinant

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SKU:
P1352-50
€185
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Description

Human CellExp™ Tim-1, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

May be involved in the moderation of asthma and allergic diseases

Biomolecule/Target: Tim-1

Alternates names: TIM1; KIM1; TIMD1; Hepatitis A Virus Cellular Receptor 1; HAVcr-1; T Cell Immunoglobulin and Mucin Domain-containing Protein 1; T Cell Membrane Protein 1

Synonyms: TIM1; KIM1; TIMD1; Hepatitis A Virus Cellular Receptor 1; HAVcr-1; T Cell Immunoglobulin and Mucin Domain-containing Protein 1; T Cell Membrane Protein 1

Background Information: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Reconstitution Instructions: Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

NCBI Gene Symbol: HAVCR1

Gene ID: 26762

NCBI Accession: Q96D42

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<5 EU/μg by LAL method
Activity (Specifications/test method):
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells
Biological activity:
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells
Results:
N/A
Molecular Weight:
110 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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