SIRT7 (2-400 aa) (His-tagged), Human recombinant

SIRT7 (2-400 aa) (His-tagged), Human recombinant is available at Gentaur for Next week delivery.

Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Biomolecule/Target: SIRT7

Alternates names: NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7

Synonyms: SIRT7 (2-400 aa) (His-tagged), Human recombinant

Background Information: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.

Reconstitution Instructions: N/A

NCBI Gene Symbol: SIRT7

Gene ID: 51547

NCBI Accession: Q9NRC8