Procathepsin K, rat recombinant

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SKU:
1029-50
€185
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Description

Procathepsin K, rat recombinant is available at Gentaur for Next week delivery.

Predominant proteinase responsible for the resorption of the bone matrix.

Biomolecule/Target: Procathepsin K

Alternates names: CTSK, CTSO, CTSO3

Synonyms: CTSK, CTSO, CTSO3

Background Information: Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.

Reconstitution Instructions: N/A

NCBI Gene Symbol: CATK

Gene ID: 25425

NCBI Accession: P00786

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Rat
Recombinant:
Yes
Source:
E. coli.
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
>400 mU/mg
Biological activity:
The specific activity is >400 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog # K141-100)
Results:
>400 mU/mg
Molecular Weight:
35.4 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
1 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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