Procathepsin K, mouse recombinant

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SKU:
1027-50
€185
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Description

Procathepsin K, mouse recombinant is available at Gentaur for Next week delivery.

Predominant proteinase responsible for the resorption of the bone matrix.

Biomolecule/Target: Procathepsin K

Alternates names: Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2

Synonyms: Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2

Background Information: Cathepsin K is a member of the papain cysteine proteinase family and has been identified as the predominant proteinase responsible for the resorption of the bone matrix. The enzyme cleaves proteins such as collagen type I, collagen type II and osteonectin and therefore plays a role in bone remodeling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.

Reconstitution Instructions: N/A

NCBI Gene Symbol: CATK

Gene ID: 1513

NCBI Accession: P43235

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
Yes
Source:
E. coli.
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
>1000 mU/mg (1 U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100).
Biological activity:
N/A
Results:
N/A
Molecular Weight:
35.5 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
2.5 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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