Description
PKCepsilon, Active is available at Gentaur for Next week delivery.
Phosphorylate a wide variety of protein targets
Biomolecule/Target:
Alternates names: PKC, protein kinase C, epsilon
Synonyms: PKC, protein kinase C, epsilon
Background Information: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. Protein kinase C epsilon (PRKCE), one of the PKC family members, has been shown to be involved in many different cellular functions, such as neuron channel activation (1), apoptosis (2), cardioprotection from ischemia (3, 4), heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior (5).
Reconstitution Instructions: N/A
NCBI Gene Symbol: PRKCE
Gene ID: 5581
NCBI Accession: Q02156
Additional Information
Size: |
5 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Recombinant: |
Yes |
Source: |
Baculovirus (Sf9 insect cells) |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
1258 nmol phosphate incorporated into PKCε substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay). |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
110.0 kDa |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
5µg/50 µl |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |