Thrombin, Active, Bovine Plasma (High Activity)

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SKU:
7592-100
€185
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Description

Thrombin, Active, Bovine Plasma (High Activity) is available at Gentaur for Next week delivery.

A coagulation protein and a serine protease.

Biomolecule/Target: Thrombin

Alternates names: Activated Factor IIa

Synonyms: Activated Factor IIa

Background Information: Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.

Reconstitution Instructions: Reconstitute in sterile water (100 U/ml) with 0.9% NaCl. It forms a clear solution.

NCBI Gene Symbol: F2

Gene ID: 280685

NCBI Accession: P00735

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Additional Information

Size:
100 KU
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Bovine
Recombinant:
No
Source:
Bovine plasma
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
>1500 units/mg powder.
Results:
>1500 units/mg powder.
Molecular Weight:
37 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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