Description
p38alpha, Active is available at Gentaur for Next week delivery.
Involved in a wide variety of cellular processes
Biomolecule/Target:
Alternates names: p38, mitogen-activated protein kinase 14
Synonyms: p38, mitogen-activated protein kinase 14
Background Information: p38a (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response (5).
Reconstitution Instructions: N/A
NCBI Gene Symbol: MAPK14
Gene ID: 1432
NCBI Accession: NM_139012.
Additional Information
Size: |
5 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Recombinant: |
Yes |
Source: |
Baculovirus (Sf9 insect cells) |
Purity by SDS-PAGE: |
≥90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
The specific activity of p38alpha was determined to be 77 nmol /min/mg as per activity assay protocol. |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
67.0 kDa |
Storage Temperature: |
-80°C |
Shelf Life: |
12 months |
Concentration: |
0.1mg/ml |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |