Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant

Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant is available at Gentaur for Next week delivery.

A protein that involved in RNA and/or DNA metabolism and regulation of cell growth

Biomolecule/Target: IMPDH2

Alternates names: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH

Synonyms: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH

Background Information: Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.

Reconstitution Instructions: N/A

NCBI Gene Symbol: IMPDH2

Gene ID: 3615

NCBI Accession: P12268