BioVision Proteins
Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant
- SKU:
- P1131-20
Description
Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant is available at Gentaur for Next week delivery.
A protein that involved in RNA and/or DNA metabolism and regulation of cell growth
Biomolecule/Target: IMPDH2
Alternates names: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH
Synonyms: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH
Background Information: Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.
Reconstitution Instructions: N/A
NCBI Gene Symbol: IMPDH2
Gene ID: 3615
NCBI Accession: P12268
Additional Information
Size: |
20 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E.coli |
Purity by SDS-PAGE: |
> 90% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
Measured by its ability to convert 1 μmole of IMP into XMP at 37ºC and pH 8 |
Biological activity: |
Specific activity is ≥ 0.1 U/mg in which one unit of enzyme converts 1 μmole of IMP into XMP at 37ºC and pH 8 |
Results: |
N/A |
Molecular Weight: |
57 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Liquid |
Handling: |
Centrifuge the vial prior to opening. |