Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant

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SKU:
P1131-20
£135.37
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Description

Human Inosine-5′-Monophosphate Dehydrogenase II, human recombinant is available at Gentaur for Next week delivery.

A protein that involved in RNA and/or DNA metabolism and regulation of cell growth

Biomolecule/Target: IMPDH2

Alternates names: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH

Synonyms: IMP dehydrogenase type II, IMPDH II, IMPD2, IMPDH

Background Information: Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors. IMPDH II is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. BioVision’s active human IMPDH II is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.

Reconstitution Instructions: N/A

NCBI Gene Symbol: IMPDH2

Gene ID: 3615

NCBI Accession: P12268

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Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E.coli
Purity by SDS-PAGE:
> 90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
Measured by its ability to convert 1 μmole of IMP into XMP at 37ºC and pH 8
Biological activity:
Specific activity is ≥ 0.1 U/mg in which one unit of enzyme converts 1 μmole of IMP into XMP at 37ºC and pH 8
Results:
N/A
Molecular Weight:
57 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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