Human CellExp™ VTCN1, human recombinant

Human CellExp™ VTCN1, human recombinant is available at Gentaur for Next week delivery.

Negatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation

Biomolecule/Target: VTCN1

Alternates names: B7-H4, VTCN1, B7S1, B7h.5

Synonyms: B7-H4, VTCN1, B7S1, B7h.5

Background Information: V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: VTCN1

Gene ID: 79679

NCBI Accession: Q7Z7D3