Human CellExp™ TPO, Mouse Recombinant

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SKU:
P1565-50
$719.07
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Description

Human CellExp™ TPO, Mouse Recombinant is available at Gentaur for Next week delivery.

Stimulates the proliferation and maturation of megakaryocytes

Biomolecule/Target:

Alternates names: Thpo, C-mpl ligand,ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, Mgdf, Ml, Mpllg, Tpo, thrombopoietin isoform 1

Synonyms: Thpo, C-mpl ligand,ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand, Mgdf, Ml, Mpllg, Tpo, thrombopoietin isoform 1

Background Information: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Megakaryocytopoiesis is the cellular development process that leads to platelet production. It is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Recombinant mouse Thrombopoietin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: Thpo

Gene ID: 21832

NCBI Accession: P40226

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Additional Information

Size:
50 µg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
VRAI
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS - PAGE
Endotoxin Level:
< 1 EU per 1ug of protein (determined by LAL method)
Activity (Specifications/test method):
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range ≤4ng/ml.
Biological activity:
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. The ED50 range ≤4ng/ml.
Molecular Weight:
36.4 kDa (His-tag at C-terminus)
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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