Human CellExp™ Progranulin, Mouse Recombinant

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SKU:
4734-50
€185
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Description

Human CellExp™ Progranulin, Mouse Recombinant is available at Gentaur for Next week delivery.

Regulator of cell growth, wound healing, and tumorigenesis

Biomolecule/Target:

Alternates names: Proepithelin; PEPI; PC Cell-derived Growth Factor

Synonyms: Proepithelin; PEPI; PC Cell-derived Growth Factor

Background Information: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Mouse Recombinant Progranulin fused to FLAG® at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 589 amino acids and having a molecular mass of ~70.0 kDa.

Reconstitution Instructions: N/A

NCBI Gene Symbol: GRN

Gene ID: 10090

NCBI Accession: P28798

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
<0.1 EU/μg purified protein
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
~70.0 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
0.3 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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