Human CellExp™ TIMP-2, human recombinant

Human CellExp™ TIMP-2, human recombinant is available at Gentaur for Next week delivery.

Irreversibly inactivates metalloproteinases

Biomolecule/Target: TIMP2

Alternates names: CSC-21K, TIMP2

Synonyms: CSC-21K, TIMP2

Background Information: TIMP metallopeptidase inhibitor 2 is also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family proteins are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members (TIMP1, TIMP2, TIMP3, TIMP4), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: TIMP2

Gene ID: 7077

NCBI Accession: P16035