Human CellExp™ GAD1, human recombinant

Human CellExp™ GAD1, human recombinant is available at Gentaur for Next week delivery.

Serves as a highly prostate-specific tissue biomarker

Biomolecule/Target: GAD1

Alternates names: GAD1, CPSQ1, GAD, SCP, GAD-1, CPSQ-1, GAD67, GAD-67

Synonyms: GAD1, CPSQ1, GAD, SCP, GAD-1, CPSQ-1, GAD67, GAD-67

Background Information: Glutamate decarboxylase 1 (GAD1), also known as 67 kDa glutamic acid decarboxylase and Glutamate decarboxylase 67 kDa isoform, is a member of the group II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. GAD1 may also play a role in the stiff man syndrome. Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) which is a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. GAD1 has been shown to interact with GAD2. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: GAD1

Gene ID: 2571

NCBI Accession: Q99259