Human CellExp™ PON1, Human Recombinant

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SKU:
P1556-50
$183
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Description

Human CellExp™ PON1, Human Recombinant is available at Gentaur for Next week delivery.

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides

Biomolecule/Target:

Alternates names: Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, paraoxonase 1, ESA, MVCD5, PON

Synonyms: Aromatic esterase 1, A-esterase 1, K-45, Serum aryldialkylphosphatase 1, paraoxonase 1, ESA, MVCD5, PON

Background Information: PON1, also known as A esterase1, is a member of the paraoxonase family. It is an enzyme that hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. It is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). This protein is activated by PPAR-gamma, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis. PON1 shows a variety of atheroprotective properties by metabolizing inflammatory lipid peroxides. It has evolved to be a highly promiscuous enzyme capable of hydrolysing a wide variety of substrates such as lactones, cyclic carbonates, organophosphorus pesticides and nerve gases. Recombinant human PON1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Reconstitution Instructions:

NCBI Gene Symbol: PON1

Gene ID: P27169

NCBI Accession: P27169

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Additional Information

Size:
50 µg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
FAUX
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS - PAGE
Endotoxin Level:
< 1 EU per 1ug of protein (determined by LAL method)
Activity (Specifications/test method):
Specific activity is > 2,500 pmol/min/ug
Molecular Weight:
39.0 kDa (His-tag at C-terminus)
Storage Temperature:
-20ºC
Shelf Life:
12 months
Concentration:
0.25 mg/ml (determined by Absorbance at 280nm)
Appearance:
Liquid protein
Handling:
Centrifuge the vial prior to opening.
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