Human CellExp™ PDGF-CC, Human Recombinant

Human CellExp™ PDGF-CC, Human Recombinant is available at Gentaur for Next week delivery.

Potent mitogen for a variety of cell types

Biomolecule/Target:

Alternates names: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E

Synonyms: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E

Background Information: PDGF-CC is a member of the platelet-derived growth factor (PDGF) family, which was originally identified as a serum growth factor for fibroblasts, smooth muscle cells and glia cells. The PDGF family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta). PDGF-CC is expressed in multiple embryonic and adult cell types and tissues. PDGF-CC is involved in pathogenesis of neurologic diseases, cancer and fibrosis. The PDGF-CC ligand has also been shown to be involved in tumor growth by paracrine signaling through PDGFRα in malignant melanoma and cervical carcinoma.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: PDGFC

Gene ID: 56034

NCBI Accession: Q9NRA1