BioVision Products
Human CellExp™ Osteoprotegerin / TNFRSF11B, human recombinant
- SKU:
- 7514-20
Description
Human CellExp™ Osteoprotegerin / TNFRSF11B, human recombinant is available at Gentaur for Next week delivery.
≥95% pure, active, human cell expressed, human recombinant Osteoprotegerin / TNFRSF11B - acts as decoy receptor for TNFSF11/RANKL
Biomolecule/Target: Osteoprotegerin / TNFRSF11B
Alternates names: TNFRSF11B, OCIF, OPG, Osteoprotegerin
Synonyms: TNFRSF11B, OCIF, OPG, Osteoprotegerin
Background Information: Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
NCBI Gene Symbol: TNFRSF11B
Gene ID: 4982
NCBI Accession: O00300
Additional Information
Size: |
20 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10 μg/ml (100 μl/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/ml. |
Results: |
N/A |
Molecular Weight: |
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 44.4 kDa. The predicted N-terminus is Glu 22. DTT-reduced Protein migrates as 55 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |