Human CellExp™ Osteoprotegerin / TNFRSF11B, human recombinant

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SKU:
7514-20
£135.37
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Description

Human CellExp™ Osteoprotegerin / TNFRSF11B, human recombinant is available at Gentaur for Next week delivery.

≥95% pure, active, human cell expressed, human recombinant Osteoprotegerin / TNFRSF11B - acts as decoy receptor for TNFSF11/RANKL

Biomolecule/Target: Osteoprotegerin / TNFRSF11B

Alternates names: TNFRSF11B, OCIF, OPG, Osteoprotegerin

Synonyms: TNFRSF11B, OCIF, OPG, Osteoprotegerin

Background Information: Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

NCBI Gene Symbol: TNFRSF11B

Gene ID: 4982

NCBI Accession: O00300

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Additional Information

Size:
20 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10 μg/ml (100 μl/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/ml.
Results:
N/A
Molecular Weight:
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 44.4 kDa. The predicted N-terminus is Glu 22. DTT-reduced Protein migrates as 55 kDa due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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