Human CellExp™ Nectin-2 / CD112, Human Recombinant

Human CellExp™ Nectin-2 / CD112, Human Recombinant is available at Gentaur for Next week delivery.

Modulator of T-cell signaling.

Biomolecule/Target: NECTIN2

Alternates names: CD112, Nectin-2, PVRL2

Synonyms: CD112, Nectin-2, PVRL2

Background Information: Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 100 µg/ml.

NCBI Gene Symbol: NECTIN2

Gene ID: 5819

NCBI Accession: Q92692