BioVision Products
Human CellExp™ LRRC4 /NGL-2, human recombinant
- SKU:
- 7461-50
Description
Human CellExp™ LRRC4 /NGL-2, human recombinant is available at Gentaur for Next week delivery.
Regulates the formation of excitatory synapses through the recruitment of pre-and-postsynaptic proteins
Biomolecule/Target: LRRC4 /NGL-2
Alternates names: LRRC4, NGL-2, BAG, NAG14.
Synonyms: LRRC4, NGL-2, BAG, NAG14.
Background Information: LRRC4 (Leu-rich repeat/LRR-containing glycoprotein 4), LRRC4B and LRRC4C are post-synaptic adhesion molecules of the LRR protein family that induce excitatory synapse formation. LRRC4 is also known as Brain tumor-associated protein BAG, Netrin-G2 ligand (NGL-2), Nasopharyngeal carcinoma-associated gene 14 protein (NAG14), which contains 1 Ig-like (immunoglobulin-like) domain and 9 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain. LRRC4 / NGL-2 specifically expressed in brain. LRRC4 / NGL-2 regulates the formation of excitatory synapses through the recruitment of pre-and-postsynaptic proteins. LRRC4 / NGL-2 organize the lamina/pathway-specific differentiation of dendrites. LRRC4 / NGL-2 plays an important role for auditory synaptic responses and involved in the suppression of glioma.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: LRRC4
Gene ID: 64101
NCBI Accession: Q9HBW1
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥92% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant mouse Netrin-G2a Fc chimera at 4 μg/ml, can bind rhLRRC4 with an apparent KD < 10 nM. |
Results: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant mouse Netrin-G2a Fc chimera at 4 μg/ml, can bind rhLRRC4 with an apparent KD < 10 nM. |
Molecular Weight: |
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 55.6 kDa. The predicted N-terminus is Ala 39. DTT-reduced Protein migrates as 90-110 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |