Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant

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SKU:
P1207-50
€185
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Description

Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Binds to TGF-beta to suppress naïve T cell proliferation.

Biomolecule/Target: LRRC32

Alternates names: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant

Synonyms: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant

Background Information: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: LRRC32

Gene ID: 2615

NCBI Accession: Q14392

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
> 95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per/μg
Activity (Specifications/test method):
Measured by its binding ability in a functional ELISA.
Biological activity:
Immobilized Latent TGFB1, N-His at 5 μg/mL (100 μL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 μg/mL.
Results:
N/A
Molecular Weight:
92.6 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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