BioVision Proteins
Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant
- SKU:
- P1207-50
Description
Human CellExp™ LRRC32 / GARP, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.
Binds to TGF-beta to suppress naïve T cell proliferation.
Biomolecule/Target: LRRC32
Alternates names: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant
Synonyms: GARP, Garpin, D11S833E, Glycoprotein A repetitions predominant
Background Information: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: LRRC32
Gene ID: 2615
NCBI Accession: Q14392
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
> 95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per/μg |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA. |
Biological activity: |
Immobilized Latent TGFB1, N-His at 5 μg/mL (100 μL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 μg/mL. |
Results: |
N/A |
Molecular Weight: |
92.6 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |