Human CellExp™ LEFTY-I, Human Recombinant

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SKU:
4873-50
$183
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Description

Human CellExp™ LEFTY-I, Human Recombinant is available at Gentaur for Next week delivery.

Plays a role in left-right asymmetry determination of organ systems during development

Biomolecule/Target:

Alternates names: Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B

Synonyms: Human Recombinant LEFTY-I

Background Information: BioVision’s LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media. Lefty proteins function as an antagonist of the Nodal Signaling pathway. Proper functioning of Lefty is crucial to the proper development of the heart, lungs, spleen, and liver.

Reconstitution Instructions: Reconstitute in sterile water.

NCBI Gene Symbol: LEFTY1

Gene ID: 10637

NCBI Accession: O75610

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Human 293 cells
Purity by SDS-PAGE:
≥90%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
<0.1 ng/μg
Activity (Specifications/test method):
N/A
Biological activity:
The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse Chondrogenic cell line).
Results:
Typically 10 to 40 ng/mL ED50.
Molecular Weight:
38 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized protein
Handling:
Centrifuge the vial prior to opening.
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