Human CellExp™ Kallikrein-3, human recombinant

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SKU:
7415-10
£135.37
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Description

Human CellExp™ Kallikrein-3, human recombinant is available at Gentaur for Next week delivery.

Has important applications in the diagnosis of prostate cancer.

Biomolecule/Target: Kallikrein-3

Alternates names: PSA, KLK3, KLKB1, Kallikrein-3, APS, KLK2A1, PSA, Hk3, Seminin, Semenogelase

Synonyms: PSA, KLK3, KLKB1, Kallikrein-3, APS, KLK2A1, PSA, Hk3, Seminin, Semenogelase

Background Information: Kallikrein-3 (KLK3) is also known as Prostate-specific antigen (PSA), APS, Gamma-seminoprotein (Seminin), P-30 antigen, Semenogelase, is a glycoprotein enzyme, is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. The preferential cleavage site of KLK3 is “-Tyr-|-Xaa-“, the catalytic activity is inhibited by SERPINA5 and is strongly inhibited by Zn2+. KLK3 hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: KLK3

Gene ID: 3818

NCBI Accession: P03952

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Additional Information

Size:
10 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥92%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
Measured by its ability to cleave the colorimetric peptide substrate, Succinyl – Arg – Pro – Tyr – p – Nitroanilide (Suc-RPY-pNA). The specific activity is >60 pmoles / min / μg.
Results:
Measured by its ability to cleave the colorimetric peptide substrate, Succinyl – Arg – Pro – Tyr – p – Nitroanilide (Suc-RPY-pNA). The specific activity is >60 pmoles / min / μg.
Molecular Weight:
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 27.7 kDa. The predicted N-terminus is Ala 18. DTT-reduced Protein migrates as 36 kDa due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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