Human CellExp™ IL-4 Rα, Human Recombinant

Human CellExp™ IL-4 Rα, Human Recombinant is available at Gentaur for Next week delivery.

A receptor for both interleukin 4 and interleukin 13

Biomolecule/Target: IL-4 Rα

Alternates names: soluble IL-4 receptor alpha, CD124

Synonyms: soluble IL-4 receptor alpha, CD124

Background Information: IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains in addition to the γc an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL- 4Rα.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to - 80°C

NCBI Gene Symbol: IL4RA

Gene ID: 3566

NCBI Accession: P24394