Human CellExp™ IL-2 R alpha / CD25, Mouse Recombinant

Human CellExp™ IL-2 R alpha / CD25, Mouse Recombinant is available at Gentaur for Next week delivery.

Extracellular Domain of IL-2R fused to 6x His tag at the C-terminus.

Biomolecule/Target:

Alternates names: IL2RA, CD25, p55, IL2-RA, IL-2-RA

Synonyms: IL2RA, CD25, p55, IL2-RA, IL-2-RA

Background Information: Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Il2ra

Gene ID: 16184

NCBI Accession: P01590