Human CellExp™ IL-2 R alpha / CD25, Mouse Recombinant

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SKU:
P1464-50
$183
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Description

Human CellExp™ IL-2 R alpha / CD25, Mouse Recombinant is available at Gentaur for Next week delivery.

Extracellular Domain of IL-2R fused to 6x His tag at the C-terminus.

Biomolecule/Target:

Alternates names: IL2RA, CD25, p55, IL2-RA, IL-2-RA

Synonyms: IL2RA, CD25, p55, IL2-RA, IL-2-RA

Background Information: Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Il2ra

Gene ID: 16184

NCBI Accession: P01590

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Biological activity:
Immobilized Biotinylated Human IL-2, Fc Tag, A at 5 μg/mL (100 μL/well) on streptavidin precoated (0.5 μg/well) plate, can bind Mouse IL-2 R alpha with a linear range of 5-40 ng/mL. Immobilized Mouse IL-2 R alpha at 5 μg/mL (100 μL/well) can bind Bio
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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