Human CellExp™ CD25/IL-2R alpha, C-His Tag, Human Recombinant

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SKU:
P1303-50
€185
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Description

Human CellExp™ CD25/IL-2R alpha, C-His Tag, Human Recombinant is available at Gentaur for Next week delivery.

Extracellular Domain of IL-2R fused to 6x His tag at the C-terminus.

Biomolecule/Target: IL-2R

Alternates names: IL2RA, Interleukin-2 receptor subunit alpha, p55, CD25, IL2-RA, TAC antigen,

Synonyms: IL2RA, Interleukin-2 receptor subunit alpha, p55, CD25, IL2-RA, TAC antigen,

Background Information: Interleukin-2 receptor subunit alpha (IL2RA) is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells. IL2RA binds IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covalently with the IL2 receptor beta and gamma chain, and subsequently initiates intracellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been considered as an activation marker. While both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.

NCBI Gene Symbol: IL2RA

Gene ID: 3559

NCBI Accession: P01589

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
This protein is fused to 6x His tag at the C-terminus and has a calculated MW of 26 kDa. The protein behaves as ~55 kDa and ~100 kDa polypeptide under reducing (R) and non-reducing (NR) conditions (SDS-PAGE) due to glycosylation and dimerization.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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