BioVision Proteins
Human CellExp™ IL-15 R alpha / CD215, Fc Tag, Human recombinant
- SKU:
- P1424-50
Description
Human CellExp™ IL-15 R alpha / CD215, Fc Tag, Human recombinant is available at Gentaur for Next week delivery.
High-affinity receptor for interleukin-15.
Biomolecule/Target:
Alternates names: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha
Synonyms: IL15RA, IL-15RA, IL-15R-alpha, IL-15 receptor subunit alpha
Background Information: IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein. High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor. Signal transduction involves SYK. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: IL15RA
Gene ID: Q13261
NCBI Accession: Q13261
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
False |
Source: |
HEK 293 Cells |
Purity by SDS-PAGE: |
>95% |
Assay: |
SDS-PAGE |
Endotoxin Level: |
Less than 1.0 EU per μg by the LAL method. |
Activity (Specifications/test method): |
Immobilized Human IL-15 R alpha, Fc Tag at 2 μg/ml (100 μl/well) can bind Biotinylated Human IL-15 with a linear range of 2-78 ng/ml. |
Molecular Weight: |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |