BioVision Proteins
Human CellExp™ ICOS / CD278, Human recombinant
- SKU:
- 9238-100
Description
Human CellExp™ ICOS / CD278, Human recombinant is available at Gentaur for Next week delivery.
Inducible T-cell costimulator
Biomolecule/Target: CD278
Alternates names: ICOS, CD278, AILIM
Synonyms: ICOS, CD278, AILIM
Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
NCBI Gene Symbol: CD278
Gene ID: 29851
NCBI Accession: NP_036224
Additional Information
Size: |
100 µg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
N/A |
Assay: |
N/A |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1 EU/μg |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA. |
Biological activity: |
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml. |
Results: |
N/A |
Molecular Weight: |
This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |