BioVision Proteins
Human CellExp™ ICOS / CD278, Mouse Recombinant
- SKU:
- P1469-50
Description
Human CellExp™ ICOS / CD278, Mouse Recombinant is available at Gentaur for Next week delivery.
Inducible T-cell costimulator
Biomolecule/Target:
Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator
Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator
Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: Icos
Gene ID: 54167
NCBI Accession: Q9WVS0-1
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Mouse |
Recombinant: |
True |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
>90% |
Assay: |
SDS-PAGE |
Endotoxin Level: |
Less than 1.0 EU per μg by the LAL method. |
Biological activity: |
Immobilized Human B7-H2 at 1 μg/mL (100 μL/well) can bind Mouse ICOS with a linear range of 0.01-0.2ng/mL |
Molecular Weight: |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |