Human CellExp™ HMGB1 /HMG1, Mouse Recombinant

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SKU:
P1465-50
€185
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Description

Human CellExp™ HMGB1 /HMG1, Mouse Recombinant is available at Gentaur for Next week delivery.

A DNA vaccine adjuvant and a target for cancer therapy.

Biomolecule/Target:

Alternates names: HMGB1, HMG1, HMG3, SBP-1

Synonyms: HMGB1, HMG1, HMG3, SBP-1

Background Information: High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Hmgb1

Gene ID: 15289

NCBI Accession: P63158

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.8 kDa. The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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