BioVision Products
Human CellExp™ HMGB1 /HMG1, human recombinant
- SKU:
- 7240-50
Description
Human CellExp™ HMGB1 /HMG1, human recombinant is available at Gentaur for Next week delivery.
A DNA vaccine adjuvant and a target for cancer therapy.
Biomolecule/Target: HMGB1
Alternates names: HMGB1, HMG1, HMG3, SBP-1
Synonyms: HMGB1, HMG1, HMG3, SBP-1
Background Information: High-mobility group protein B1 (HMGB1), also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It is also involved in inflammation and damage by binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4. Do not vortex. Store the solution in aliquots at -20°C for long term storage.
NCBI Gene Symbol: HMGB1
Gene ID: 3146
NCBI Accession: P09429
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
HPLC |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA HMGB1 is binding to immobilized human AGER-Fc tag protein (100 μg/well) with a linear range of 0.31-2.5 µg/ml. |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
25 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |