BioVision Proteins
Human CellExp™ Gremlin / GREM1, Human recombinant
- SKU:
- P1124-50
Description
Human CellExp™ Gremlin / GREM1, Human recombinant is available at Gentaur for Next week delivery.
A TGF-β antagonist
Biomolecule/Target: Grem1
Alternates names: GREM1, CKTSF1B1, DAND2, DRM, PIG2
Synonyms: GREM1, CKTSF1B1, DAND2, DRM, PIG2
Background Information: Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: Grem1
Gene ID: 23892
NCBI Accession: O70326
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
> 95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per/μg |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA. |
Biological activity: |
Immobilized Human BMP-2, at 2 μg/mL (100 μL/well) can bind Human Gremlin, His Tag with a linear range of 0.8-81.9 ng/mL. |
Results: |
N/A |
Molecular Weight: |
20.2 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |