Human CellExp™ GM-CSF, Human Recombinant

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SKU:
6454-50
£135.37
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Description

Human CellExp™ GM-CSF, Human Recombinant is available at Gentaur for Next week delivery.

A glycoprotein, growth factor and cytokine that stimulates the bone marrow to produce granulocytes and stem cells

Biomolecule/Target:

Alternates names: CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim, MGC131935, MGC138897.

Synonyms: Human Cellexp Human Recombinant GM-CSF

Background Information: Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a growth factor that supports the in-vitro colony formation of granulocytes-macrophages progenitor cells. It is a pleiotropic cytokine and is produced as a response to immune or inflammatory stimuli by activated cells of the hematopoietic system such as T cells, B cells, macrophages, mast cells, fibroblasts and alveolar epithelial cells. It plays an important role in regulating the proliferation, differentiation, survival and activation of hematopoietic cells such as granulocytes and monocytes, neutrophiles, basophiles and eosonophoiles, erythroid cells, megakaryocytes and T cells. Human and mouse GM-CSF have about 56% homology and are species specific. Human GM-CSF is not active on mouse cells and vice versa. It is active on canine and feline cells.

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

NCBI Gene Symbol: CSF2

Gene ID: 1437

NCBI Accession: P04141

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Human 293 cell expressed
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per 1 μg of protein
Activity (Specifications/test method):
N/A
Biological activity:
ED₅₀ is typically 0.4 to 2 ng/mL. The specific activity was determined by the dose- Dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic Indicator cell line).
Results:
0.4 to 2 ng/ml
Molecular Weight:
15 to 36 kDa, monomer, glycosylated
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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