Human CellExp™ GITR / TNFRSF18, Human recombinant

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SKU:
9231-50
$183
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Description

Human CellExp™ GITR / TNFRSF18, Human recombinant is available at Gentaur for Next week delivery.

Tumor necrosis factor receptor superfamily member 18

Biomolecule/Target: GITR

Alternates names: AITR, GITR, TNFRSF18, CD358

Synonyms: AITR, GITR, TNFRSF18, CD358

Background Information: Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Reconstitution Instructions: Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml

NCBI Gene Symbol: TNFRSF19

Gene ID: 8784

NCBI Accession: Q9Y5U5-2

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥92%
Assay:
SDS-PAGE
Purity:
≥92%
Assay 2:
N/A
Endotoxin Level:
< 1 EU/μg
Activity (Specifications/test method):
Measured by its binding ability in a functional ELISA.
Biological activity:
Immobilized Human GITR/TNFRSF18, His Tag at 2 µg/mL (100 µL/well) can bind r-Human GITR Ligand /TNFSF18 with a linear range of 0.8-25 ng/mL.
Results:
N/A
Molecular Weight:
This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 15.4 kDa. The protein migrates as 22-25 kDa in SDS-PAGE due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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