BioVision Products
Human CellExp™ CNTN2/Contactin-2, human recombinant
- SKU:
- 7442-50
Description
Human CellExp™ CNTN2/Contactin-2, human recombinant is available at Gentaur for Next week delivery.
Mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules.
Biomolecule/Target: CNTN2/Contactin-2
Alternates names: CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, TAX, TAX1, TAX-1, Contactin-2
Synonyms: CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, TAX, TAX1, TAX-1, Contactin-2
Background Information: Contactin-2 also known as CNTN2, TAX1 (transiently-expressed axonal glycoprotein), TAG1 (transient axonal glycoprotein), and axonin-1, and is a member of the immunoglobulin superfamily. CNTN2 consists of six Ig-like domains and four fibronectin type III domains, and is anchored to the membrane by glycosylphosphatidylinositol (GPI), whereas the soluble form can be released by a GPI-specific phospholipase. As a neural cell adhesion molecule expressed by a subset of neuronal populations in the developing CNS and PNS, CNTN2 mediates cell-cell interactions either via homophilic, or heterophilic contacts with various adhesion molecules including NgCAM, NrCAM, NCAM and neurocan. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
NCBI Gene Symbol: CNTN2
Gene ID: 6900
NCBI Accession: Q02246
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
<1 EU/μg by LAL method |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Optimal neurite outgrowth was observed when neurons were plated on 96-well culture plates that had been precoated with 50 μl/well of the rhContactin2 solu |
Results: |
Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Optimal neurite outgrowth was observed when neurons were plated on 96-well culture plates that had been precoated with 50 μl/well of the rhContactin2 solu |
Molecular Weight: |
This protein is fused with 6×his tag at the C-terminus and has a calculated MW of 109 kDa expressed. The predicted N-terminus is Ser 31. Protein migrates as 140 kDa in reduced SDS-PAGE resulting from glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |