HDAC-3, human recombinant

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SKU:
7613-250
$183
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Description

HDAC-3, human recombinant is available at Gentaur for Next week delivery.

A potential tumor suppressor gene

Biomolecule/Target:

Alternates names: Histone deacetylase 3, HD3, RPD3-2, SMAP45

Synonyms: HDAC-3, HDAC3, HDAC 3, Histone deacetylase 3

Background Information: Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).

Reconstitution Instructions: N/A

NCBI Gene Symbol: HDAC3

Gene ID: 8841

NCBI Accession: O15379

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Additional Information

Size:
250 units
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Sf9 insect cells
Purity by SDS-PAGE:
≥50%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
N/A
Activity (Specifications/test method):
Activity of rh-HDAC3 was tested using Arg-His-Lys-Lys(Ac)-AFC, a fluorogenic, acetylated peptide based on residues 379-382 of p53 as a substrate. ≥ 0.5 U/µl
Biological activity:
N/A
Results:
N/A
Molecular Weight:
51.1kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
0.5U/µl
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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